PhD defence of Pablo Jeken Rico

Advanced Hemodynamic Modelling and Simulation of Flow Diverters in the Treatment of Intracranial Aneurysms

Pablo Jeken Rico conducted his PhD work in the CFL team under the supervision of Elie Hachem, Aurélien Larcher (CEMEF) and Figliuzzi (CMM). He will defend his PhD in Computational Mathematics, High Performance Computing and Data, on September 25th, 2024 in front of the following jury:

M. Umberto MORBIDUCCI Politecnico di Torino Reviewer
M. Marek BEHR RWTH Aachen Reviewer
Mme Anne-Virginie SALSAC Université de Technologie de Compiègne Examiner
M. Elie HACHEM Cemef, Mines Paris – PSL Examiner
M. Aurélien LARCHER Cemef, Mines Paris – PSL Examiner
M. Bruno FIGLIUZZI CMM, Mines Paris – PSL Examinater

Abstract:

The core of the thesis work has been dedicated to the study of intracranial aneurysms using fluid dynamics simulations. To attain high-fidelity representations of the bio-mechanical interactions, a computational framework has been designed, including new additions to the field of simulation techniques, validation cases and meshing routines. The framework has then been adapted to the special environment of brain arteries considering medical and anatomical aspects. In addition, a virtual flow-diverter deployment has been developed to permit the analysis of complex cases involving the post-treatment remodelling. Lastly, the framework is exploited to simulate the fluid dynamics in several patient cases, suffering rare and complex forms of aneurysms that are still poorly understood.

Keywords: Computational Fluid Dynamics, Intracranial Aneurysms, Flow Diverters, Patient-specific modelling, Circle of Willis, Variational Multiscale Method